Hulk (1962) #103
"And Now ... the Space Parasite!" is written by Gary Friedrich and drawn by Marie Severin and Frank Giacoia. Beamed down from his misadventures in Asgard, the Hulk finds himself in Manhattan. But the Big Green and the Big Apple don't mix well especially with so many people crowding around and tall buildings beckoning the gamma-ray giant to knock them down. But soon the Hulk makes his miraculous transformation into the tragic figure of Dr. Bruce Banner who is left to pick up the shattered pieces of his life. New York City is safe, for the moment.
But the peace Banner and the city seeks is not fated to be theirs as from outer space, a new menace rears its head. The Space Parasite, a monarch of a normally peace-loving people, imbued with incredible power meant to be used against their enemies, seeks a new conquest. Exiled from his planet by the people he once ruled, Randau the Space Parasite, picks a fight with Earth's mightiest mortal, the ever-loving Hulk himself. As the terrified Betty Ross looks on, the Hulk battles a foe who can drain his very strength from his muscles. Will this be the Hulk's final battlefield?